experimental determination of ht29 cancerous cell surface roughness by atomic force microscopy to be applied in nanomanipulation

in this paper, surface roughness of ht29 cancerous is determined using topography images obtained by atimic force microscopy (afm). the mean radiuses of cell and substrate surface asperities are determined, based on results of conducted roughness analysis and rabinovich roughness theory. these values have been applied in the equations of rough particle nanomanipulation dynamic model and the amounts of critical force and time are simulated. based on results, the rolling mode is the dominant dynamic mode at the onset of cells movement and the analysis based on rabinovich model predict lower amounts of critical force and time compared to rumpf model based analysis.